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4-AcO-DMT (or psilacetin) is a semi-synthetic tryptamine closely related to the “magic mushroom” molecules psilocin and psilocybin. Like psilocybin, it appears to be metabolized by the body into psilocin.
Most people buy psilacetin as a brown or off-white powder that can be mixed with water just prior to dosing. But it’s also available in pills, tablets, capsules, and gel tabs among other preparations.
When taken as a drug in its purified or synthetic form,4-MeO DMT is vaporized, insufflated, or injected and is active at a dose of as little as 2 mg. 4-MeO DMT is active orally when taken with an MAOI, but according to numerous reports, this combination often tends to be extremely unpleasant and has a strong body load.
4-AcO-DMT is usually sold as a fumarate salt (4-AcO-DMT fumarate) containing on average 1 mg pure 4-AcO-DMT for every 1.24 mg of the powder. If it’s a hydrochloride salt (4-AcO-DMT HCl), it will contain on average 1 mg pure 4-AcO-DMT for every 1.15 mg of the powder. In practice the difference may be negligible, but it’s worth knowing. Given the prevalence of 4-AcO-DMT fumarate—and that it contains less of the active indole alkaloid—it’s safe to assume dosage guidelines found online pertain to the fumarate salt.
As a powder, 4-AcO-DMT is usually taken orally, but it can also be taken intranasally (snorted/insufflated). For other methods see FAQ. Either way, it’s processed more rapidly by the body than psilocybin mushrooms, typically resulting in a faster, more intense onset.
The body also converts 4-AcO-DMT (Figure 3) to psilocin via removal of the acetyl group by deacetylase and acetyltransferase enzymes. Scientists don’t know if 4-AcO-DMT is biologically active on its own. Interestingly, in their 1963 patent, Albert Hofmann and Franz Troxler described indole acetate esters like 4-AcO-DMT as serotonin receptor antagonists. However, over the years, scientists have come to classify them as prodrugs that are inactive on their own by way of analogy to psilocybin.
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EFFECTS OF 4 Aco DMT
Tactile enhancement – This particular component is perhaps the most overwhelming sensation within the entirety of the 4-ACO DMT experience. It increases the intensity of tactile sensations to such an overwhelming extent that it can induce a sensation of sustained and repeatable full body orgasm within every nerve ending across the entire body to a degree not found within any other psychedelic drug. The experience of this results in the perception of having difficulty sustaining the act of breathing. It is worth noting, however, that this is not a genuine or dangerous experience of respiratory depression and is considered to be safe.
It’s fairly common to perceive an “additional layer” to reality, sometimes manifesting as an “energy field” around objects. Changes in perception of gravity or bodily sensations are also commonly reported. In addition to visual patterns, some people experience “external” hallucinations of seemingly autonomous entities. At high-end doses, “ego-death” is commonly reported, and many self-experimenters temporarily forget their own names
Gratitude, acceptance, trust, and letting go are some other common themes. As one psychonaut put it, “whereas mushrooms operate in a part of the brain that could be considered about language or intellect, 4-AcO-DMT acts on the emotional thought processes.” By taking 4-AcO-DMT once every couple of months, he said, he was better able to manage his “warped” emotions
As ever, it’s wise to start with a small dose and work your way up through subsequent trips. The importance of accurate measurements cannot be overstated. As one psychonaut put it, “it’s easy to accidentally swallow what would be equivalent to a trash bag of shrooms. It’s also a good idea to avoid eating for at least a couple of hours beforehand. Although nausea tends to be less common than with psilocybin mushrooms (perhaps because of the indigestible chitin they contain. upset stomachs are are common during the onset of 4-AcO-DMT